Corticosteroid hormone secretion

Across TCGA patient cohorts, RNA activity of the Corticosteroid hormone secretion pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCAN2, CXCL12, and LTBP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Corticosteroid hormone secretion activity versus RCAN2 in GBM (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RCAN2 →	+1.261	+0.507	<.001	.001	3	7
GBM	CXCL12 →	+1.090	+0.666	<.001	<.001	3	6
GBM	LTBP2 →	+1.224	+0.560	<.001	.002	3	6
GBM	PIMREG →	-0.970	-0.642	.002	<.001	3	6
LUAD	HPGDS →	+0.943	+0.410	<.001	<.001	3	6
LSCC	AXL →	+0.925	+0.648	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035930 vs RCAN2 — GBM

Explore this scatter interactively →