Corticosteroid hormone secretion

Across TCGA cell cohorts, RNA activity of the Corticosteroid hormone secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSD17B4, MUSK, and N4BP2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HSD17B4 grouped by Corticosteroid hormone secretion-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HSD17B4 →	-0.266	-0.192	.002	.007	3	3
STOMACH	MUSK →	-0.167	-1.197	.002	.004	3	3
LARGE_INTESTINE	N4BP2 →	-0.213	-1.100	.003	.002	3	3
SKIN	FN3KRP →	-0.164	-1.007	.002	.003	3	3
SKIN	FBXL2 →	-0.147	-1.230	.009	.001	3	3
SKIN	IRX3 →	-0.198	-0.966	.008	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HSD17B4 by Corticosteroid hormone secretion activity — BLOOD_Lymphoma

Explore this box plot interactively →