Steroid hormone secretion

Across TCGA patient cohorts, RNA activity of the Steroid hormone secretion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HSPG2, TNS2, and TNS2_S120, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Steroid hormone secretion activity versus HSPG2 in GBM (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HSPG2 →	+0.475	+0.054	<.001	.007	3	7
BRCA	TNS2 →	+0.390	+0.039	<.001	<.001	3	7
BRCA	TNS2_S120 →	+0.508	+0.035	<.001	.001	3	7
LSCC	DDX56 →	-0.281	-0.054	<.001	<.001	3	7
PDAC	GEMIN5_S778 →	-0.565	-0.066	<.001	<.001	3	7
LSCC	POLR1E →	-0.352	-0.071	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035929 vs HSPG2 — GBM

Explore this scatter interactively →