Steroid hormone secretion

Across TCGA patient cohorts, RNA activity of the Steroid hormone secretion pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPP1, FN1, and SLC11A1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Steroid hormone secretion activity versus SPP1 in HNSC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SPP1 →	+2.817	+0.925	<.001	<.001	3	8
HNSC	FN1 →	+2.017	+1.160	<.001	<.001	3	7
GBM	SLC11A1 →	+1.024	+0.421	<.001	<.001	3	6
GBM	TREML3P →	+1.048	+0.468	<.001	<.001	3	6
CCRCC	GPX8 →	+0.395	+0.285	.007	<.001	3	6
CCRCC	LUCAT1 →	+1.209	+0.337	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035929 vs SPP1 — HNSC

Explore this scatter interactively →