Steroid hormone secretion

Across TCGA cell cohorts, RNA activity of the Steroid hormone secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP2W1, GUK1, and KCNQ2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYP2W1 grouped by Steroid hormone secretion-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CYP2W1 →	-0.190	-1.030	<.001	.007	3	6
BONE	GUK1 →	-0.194	-1.685	.001	.002	2	6
BLOOD_Myeloma	KCNQ2 →	-0.233	-1.651	.005	<.001	3	5
OESOPHAGUS	RALGAPA1P1 →	-0.200	-1.130	.002	.007	2	6
STOMACH	RAPGEF6 →	+0.283	+1.022	<.001	.005	3	5
PANCREAS	PNO1 →	+0.611	+1.308	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYP2W1 by Steroid hormone secretion activity — SOFT_TISSUE

Explore this box plot interactively →