RNA import into mitochondrion

Across TCGA patient cohorts, RNA activity of the RNA import into mitochondrion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PNPT1, TST, and RBPJ, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA import into mitochondrion activity versus PNPT1 in LSCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PNPT1 →	+0.498	+0.056	<.001	.001	3	7
HNSC	TST →	+0.434	+0.069	<.001	.001	3	6
GBM	RBPJ →	-0.300	-0.063	<.001	<.001	3	6
HNSC	PEX1 →	+0.287	+0.082	.002	.007	3	5
LSCC	PES1 →	+0.325	+0.061	<.001	<.001	3	5
CCRCC	MPST →	+0.241	+0.047	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035927 vs PNPT1 — LSCC

Explore this scatter interactively →