RNA import into mitochondrion

Across TCGA cell cohorts, RNA activity of the RNA import into mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF500, SYT11, and MGAT5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF500 grouped by RNA import into mitochondrion-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZNF500 →	-0.787	-0.296	<.001	.003	3	4
LUNG_SCLC	SYT11 →	-3.528	-0.337	.001	.001	3	3
LUNG_SCLC	MGAT5 →	-1.708	-0.393	.004	.003	3	3
STOMACH	LARGE1 →	+1.303	+0.344	.002	<.001	3	3
CNS	KAT14 →	-1.134	-1.862	.007	.004	2	3
KIDNEY	COPS9 →	+1.069	+0.350	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF500 by RNA import into mitochondrion activity — LUNG_SCLC

Explore this box plot interactively →