Skeletal muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Skeletal muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALG8, SNRPE, and ZBTB12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle cell differentiation activity versus ALG8 in BRCA (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ALG8 →	+0.613	+0.486	.001	.007	3	4
BRCA	SNRPE →	+0.288	+0.456	.003	<.001	3	4
BRCA	ZBTB12 →	+0.652	+0.620	.002	.002	2	5
GBM	GINS1 →	+0.655	+0.911	<.001	.002	3	4
GBM	ATAD2 →	+0.670	+0.856	<.001	.004	3	4
GBM	XRCC2 →	+1.042	+1.096	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035914 vs ALG8 — BRCA

Explore this scatter interactively →