Skeletal muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Skeletal muscle cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDNRA, RNASE2, and TNFRSF10A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EDNRA grouped by Skeletal muscle cell differentiation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	EDNRA →	-0.385	-0.253	.001	.002	3	5
KIDNEY	RNASE2 →	-0.171	-0.130	.001	.004	3	5
BLOOD_Myeloma	TNFRSF10A →	+0.195	+0.168	<.001	.001	3	4
BLOOD_Myeloma	AGO3 →	-0.328	-0.181	.001	.006	3	4
OVARY	RAB17 →	-0.274	-0.141	.001	.002	3	4
OVARY	SACS →	-0.172	-0.134	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EDNRA by Skeletal muscle cell differentiation activity — URINARY_TRACT

Explore this box plot interactively →