Skeletal muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Skeletal muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LSM12, TCP1, and PAICS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle cell differentiation activity versus LSM12 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	LSM12 →	-0.775	-0.211	.003	.002	3	6
URINARY_TRACT	TCP1 →	-0.795	-0.272	<.001	.001	3	5
LUNG_NSCLC_LUAD	PAICS →	-0.963	-0.180	<.001	.003	3	5
URINARY_TRACT	STIP1 →	-0.821	-0.248	.006	.006	3	5
OVARY	TAF12 →	-0.754	-0.172	.007	.003	3	5
BONE	PNPLA6 →	-1.105	-0.163	.009	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035914 vs LSM12 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →