Aorta morphogenesis

Across TCGA patient cohorts, RNA activity of the Aorta morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINF1, TPM1, and VCAN, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aorta morphogenesis activity versus SERPINF1 in BRCA (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SERPINF1 →	+0.988	+0.052	<.001	<.001	3	9
UCEC	TPM1 →	+0.872	+0.100	<.001	<.001	3	9
OV	VCAN →	+1.102	+0.059	<.001	<.001	3	9
GBM	LAMA4 →	+0.682	+0.067	<.001	<.001	3	9
CCRCC	PCOLCE →	+0.877	+0.082	<.001	<.001	3	9
UCEC	RSU1 →	+0.619	+0.092	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035909 vs SERPINF1 — BRCA

Explore this scatter interactively →