Aorta morphogenesis

Across TCGA patient cohorts, RNA activity of the Aorta morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAGLN, CNRIP1, and RHOJ, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aorta morphogenesis activity versus TAGLN in OV (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TAGLN →	+1.213	+0.812	.001	<.001	3	8
OV	CNRIP1 →	+0.798	+0.735	<.001	<.001	3	7
UCEC	RHOJ →	+0.825	+0.741	<.001	<.001	3	7
UCEC	CNN1 →	+1.889	+0.746	<.001	<.001	3	7
UCEC	MYH11 →	+2.075	+1.359	<.001	<.001	3	7
OV	ZEB1 →	+0.912	+0.631	.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035909 vs TAGLN — OV

Explore this scatter interactively →