Aorta morphogenesis

Across TCGA cell cohorts, RNA activity of the Aorta morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT3, EVI2B, and USP4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KRT3 grouped by Aorta morphogenesis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KRT3 →	-0.184	-1.388	.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	EVI2B →	+0.156	+1.585	.009	.001	3	4
LIVER	USP4 →	+0.174	+1.625	.008	<.001	3	4
BREAST	CERS4 →	+0.281	+1.264	<.001	.001	3	4
LUNG_SCLC	NACA4P →	-0.208	-1.313	.007	.009	3	3
SKIN	MCUR1 →	+0.215	+1.788	.003	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KRT3 by Aorta morphogenesis activity — LUNG_SCLC

Explore this box plot interactively →