Ascending aorta development

Across TCGA patient cohorts, RNA activity of the Ascending aorta development pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LOX, TGFB2, and TGFB2-AS1, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ascending aorta development activity versus LOX in TGCT (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	LOX →	+2.420	+0.150	<.001	<.001	3	26
MESO	TGFB2 →	+2.050	+0.110	<.001	<.001	3	24
MESO	TGFB2-AS1 →	+2.020	+0.113	<.001	<.001	3	22
UCS	FSTL1 →	+1.355	+0.106	.002	.004	2	22
TGCT	COL1A2 →	+2.233	+0.128	<.001	<.001	3	21
TGCT	COL3A1 →	+3.099	+0.134	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035905 vs LOX — TGCT

Explore this scatter interactively →