Ascending aorta development

Across TCGA patient cohorts, RNA activity of the Ascending aorta development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINH1, LAMB1, and P4HA1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ascending aorta development activity versus SERPINH1 in OV (Pearson r = 0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SERPINH1 →	+0.599	+0.081	<.001	<.001	3	10
HNSC	LAMB1 →	+0.431	+0.099	<.001	<.001	3	9
BRCA	P4HA1 →	+0.508	+0.056	<.001	<.001	3	9
LUAD	THBS1 →	+0.950	+0.101	<.001	<.001	3	8
BRCA	SEC23A →	+0.314	+0.065	<.001	<.001	3	8
CCRCC	BMP1 →	+0.993	+0.089	.005	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035905 vs SERPINH1 — OV

Explore this scatter interactively →