Ascending aorta development

Across TCGA patient cohorts, RNA activity of the Ascending aorta development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAD2L2, SVBP, and CCNB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ascending aorta development activity versus MAD2L2 in UCEC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAD2L2 →	+0.834	+1.214	.002	<.001	3	5
UCEC	SVBP →	+0.496	+0.781	.004	<.001	3	5
GBM	CCNB1 →	+0.913	+0.829	<.001	<.001	3	5
GBM	NBAT1 →	+0.765	+0.644	<.001	.001	3	5
BRCA	NPM1P9 →	+0.356	+0.461	<.001	<.001	3	5
PDAC	CBX2 →	+0.323	+0.266	.008	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035905 vs MAD2L2 — UCEC

Explore this scatter interactively →