Aorta development

Across TCGA patient cohorts, RNA activity of the Aorta development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHOJ, LHFPL6, and PDLIM3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aorta development activity versus RHOJ in UCEC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RHOJ →	+1.173	+1.091	<.001	<.001	3	7
UCEC	LHFPL6 →	+0.955	+0.700	.002	.004	3	7
UCEC	PDLIM3 →	+1.371	+0.730	<.001	<.001	3	7
LSCC	HTR2A →	+0.316	+0.617	.007	<.001	3	6
HNSC	EIF3B →	-0.753	-0.837	<.001	<.001	3	6
HNSC	TPI1 →	-1.014	-0.652	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035904 vs RHOJ — UCEC

Explore this scatter interactively →