Aorta development

Across TCGA cell cohorts, RNA activity of the Aorta development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF264, TPRA1, and RAB28, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF264 grouped by Aorta development-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZNF264 →	-1.565	-1.974	.006	<.001	3	4
STOMACH	TPRA1 →	-0.764	-1.375	<.001	<.001	3	3
LARGE_INTESTINE	RAB28 →	+0.495	+0.455	.004	.006	3	3
LIVER	PNISR →	-0.955	-1.707	.005	<.001	3	3
LIVER	TRAF1 →	-2.192	-1.677	.001	<.001	2	4
KIDNEY	FYTTD1 →	-0.808	-0.881	.007	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF264 by Aorta development activity — BLOOD_Lymphoma

Explore this box plot interactively →