Vascular associated smooth muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Vascular associated smooth muscle cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BGN, COL6A3, and LAMA4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular associated smooth muscle cell differentiation activity versus BGN in COAD (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	BGN →	+0.903	+0.050	<.001	<.001	3	10
COAD	COL6A3 →	+0.553	+0.040	<.001	<.001	3	10
UCEC	LAMA4 →	+0.636	+0.052	<.001	<.001	3	10
CCRCC	LAMB1 →	+0.492	+0.059	<.001	<.001	3	10
UCEC	LAMC1 →	+0.443	+0.052	.002	.001	3	10
OV	NID2 →	+0.550	+0.057	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035886 vs BGN — COAD

Explore this scatter interactively →