Vascular associated smooth muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Vascular associated smooth muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IKZF1, RASSF5, and CASP4LP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular associated smooth muscle cell differentiation activity versus IKZF1 in GBM (Pearson r = -0.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IKZF1 →	+0.622	+0.470	<.001	.001	3	6
OV	RASSF5 →	+0.694	+0.729	<.001	<.001	3	5
HNSC	CASP4LP →	+0.502	+0.492	<.001	<.001	3	5
GBM	SELL →	+0.923	+0.581	.004	.001	3	5
HNSC	NFATC2 →	+0.718	+0.929	.002	<.001	3	5
GBM	FAS →	+0.628	+0.464	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035886 vs IKZF1 — GBM

Explore this scatter interactively →