Vascular associated smooth muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Vascular associated smooth muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADM, VEGFA, and WIPI1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular associated smooth muscle cell differentiation activity versus ADM in SOFT_TISSUE (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ADM →	+3.452	+0.177	<.001	<.001	3	11
SOFT_TISSUE	VEGFA →	+2.097	+0.234	<.001	<.001	3	10
SOFT_TISSUE	WIPI1 →	+1.585	+0.269	<.001	<.001	3	9
BREAST	CALU →	+0.921	+0.100	.001	.001	3	8
BONE	RRBP1 →	+1.447	+0.183	.005	.004	3	8
BREAST	APOL6 →	+1.542	+0.135	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035886 vs ADM — SOFT_TISSUE

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