Vascular associated smooth muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Vascular associated smooth muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZG16B, AAMP, and PTPN12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular associated smooth muscle cell differentiation activity versus ZG16B in BREAST (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZG16B →	-2.919	-1.152	<.001	<.001	3	4
BLOOD_Leukemia	AAMP →	-0.427	-0.256	.001	.009	3	4
BLOOD_Leukemia	PTPN12 →	+1.543	+0.236	.005	.001	2	5
SKIN	PGP →	-0.809	-0.241	<.001	.001	3	4
BREAST	ANTKMT →	-1.254	-1.295	<.001	.001	3	3
BREAST	IL9R →	-0.551	-1.170	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035886 vs ZG16B — BREAST

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