Amacrine cell differentiation

Across TCGA patient cohorts, RNA activity of the Amacrine cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CSE1L, CHD4, and CRYBG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amacrine cell differentiation activity versus CSE1L in BRCA (Pearson r = -0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CSE1L →	+0.340	+0.112	<.001	<.001	3	5
CCRCC	CHD4 →	+0.118	+0.047	<.001	.002	3	5
OV	CRYBG1 →	-0.788	-0.110	.007	<.001	3	4
OV	IGFBP2 →	+0.768	+0.124	<.001	<.001	3	4
OV	PLXNB2 →	-0.194	-0.114	.001	.003	3	4
COAD	SF3B2 →	+0.133	+0.051	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035881 vs CSE1L — BRCA

Explore this scatter interactively →