Amacrine cell differentiation

Across TCGA cell cohorts, RNA activity of the Amacrine cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLX1, NEUROD1, and BARHL2, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DLX1 grouped by Amacrine cell differentiation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	DLX1 →	-0.381	-1.594	.002	<.001	3	11
SKIN	NEUROD1 →	-0.212	-1.074	.004	.008	2	11
BLOOD_Myeloma	BARHL2 →	-0.338	-1.951	<.001	<.001	3	7
BLOOD_Myeloma	HES1 →	-0.255	-2.090	.007	.003	1	8
BLOOD_Myeloma	DLX2 →	-0.408	-2.667	<.001	<.001	2	7
LUNG_NSCLC_LUAD	FOXN4 →	-0.182	-0.898	<.001	.002	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DLX1 by Amacrine cell differentiation activity — KIDNEY

Explore this box plot interactively →