Amacrine cell differentiation

Across TCGA cell cohorts, RNA activity of the Amacrine cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFBR1, PLRG1, and SLC27A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TGFBR1 grouped by Amacrine cell differentiation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TGFBR1 →	+1.122	+1.613	<.001	<.001	3	4
URINARY_TRACT	PLRG1 →	-1.286	-1.951	.008	<.001	3	4
URINARY_TRACT	SLC27A1 →	+0.935	+2.062	.008	<.001	3	4
LUNG_NSCLC_LUSC	MRC2 →	+2.694	+1.358	<.001	<.001	3	4
LUNG_NSCLC_LUSC	FMNL3 →	+1.658	+1.479	<.001	<.001	3	4
OESOPHAGUS	MAGED1 →	+2.541	+0.962	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TGFBR1 by Amacrine cell differentiation activity — SKIN

Explore this box plot interactively →