Amacrine cell differentiation

Across TCGA cell cohorts, RNA activity of the Amacrine cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZMIZ2, CCDC172, and SOX11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZMIZ2 grouped by Amacrine cell differentiation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ZMIZ2 →	-0.118	-0.126	.005	.004	3	5
BREAST	CCDC172 →	+0.449	+0.158	.001	.008	3	5
KIDNEY	SOX11 →	+0.191	+0.113	.002	.004	3	4
BONE	CCDC47 →	+0.211	+0.336	.002	.004	3	4
BONE	TMEM97 →	+0.420	+0.436	.006	.001	3	4
LUNG_SCLC	DERL3 →	+0.312	+1.911	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZMIZ2 by Amacrine cell differentiation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →