Nail development

Across TCGA patient cohorts, RNA activity of the Nail development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CEP170, UBXN10_S87, and LRBA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nail development activity versus CEP170 in LSCC (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CEP170 →	-0.279	-0.095	<.001	<.001	3	6
LUAD	UBXN10_S87 →	+0.752	+0.094	<.001	.002	3	6
UCEC	LRBA →	+0.306	+0.112	<.001	.003	3	6
LSCC	TMC5_S184 →	+1.195	+0.066	<.001	.004	3	5
LSCC	CAMSAP2 →	-0.220	-0.068	.009	<.001	3	5
CCRCC	FKBP10 →	-0.439	-0.082	.001	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035878 vs CEP170 — LSCC

Explore this scatter interactively →