Nail development

Across TCGA cell cohorts, RNA activity of the Nail development pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADK, RSRC2, and CENPA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADK grouped by Nail development-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ADK →	+1.144	+1.200	<.001	<.001	3	5
SOFT_TISSUE	RSRC2 →	-0.691	-1.082	.001	.002	3	4
OESOPHAGUS	CENPA →	+0.835	+1.077	.009	.007	3	4
OESOPHAGUS	TEAD4 →	+0.737	+1.110	.001	.007	3	4
LIVER	S100A1 →	-2.363	-1.498	.006	<.001	2	5
SOFT_TISSUE	FOXC2 →	+2.218	+1.312	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADK by Nail development activity — SKIN

Explore this box plot interactively →