Nail development

Across TCGA cell cohorts, RNA activity of the Nail development pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPTSSA, PHOX2A, and CEP70, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPTSSA grouped by Nail development-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SPTSSA →	-0.210	-1.719	.001	<.001	3	4
STOMACH	PHOX2A →	+0.168	+0.464	.009	.005	3	4
LUNG_NSCLC_LUAD	CEP70 →	+0.135	+0.264	.003	.004	3	3
LUNG_NSCLC_LUAD	HSPD1 →	-0.257	-0.207	.003	.004	3	3
BLOOD_Leukemia	SLC16A7 →	-0.275	-1.352	<.001	<.001	3	3
SOFT_TISSUE	ZNF274 →	-0.168	-0.208	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPTSSA by Nail development activity — BLOOD_Myeloma

Explore this box plot interactively →