Nail development

Across TCGA cell cohorts, RNA activity of the Nail development pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDHB, ANKRD36, and SETD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SDHB grouped by Nail development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SDHB →	-0.361	-0.639	.002	.008	3	4
LIVER	ANKRD36 →	+0.170	+0.509	.004	<.001	3	3
SKIN	SETD2 →	+0.154	+0.246	.005	.004	3	3
SKIN	ZNF75D →	-0.197	-0.248	.001	.006	3	3
LIVER	FOXN4 →	+0.190	+0.575	.001	.002	2	3
LIVER	OR13G1 →	+0.126	+0.509	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SDHB by Nail development activity — BREAST

Explore this box plot interactively →