Nail development

Across TCGA cell cohorts, RNA activity of the Nail development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA2, UPK1B, and TINAGL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nail development activity versus ANXA2 in LUNG_NSCLC_LUAD (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ANXA2 →	+0.623	+0.467	<.001	.003	3	5
LIVER	UPK1B →	+3.649	+0.431	<.001	<.001	3	5
BREAST	TINAGL1 →	+3.463	+0.724	<.001	.002	3	5
SKIN	RTN4 →	+0.830	+0.371	.009	<.001	3	4
URINARY_TRACT	RASSF5 →	+2.507	+0.434	.002	.001	3	4
URINARY_TRACT	ARAP2 →	+1.582	+0.383	.009	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035878 vs ANXA2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →