Lactate transmembrane transport

Across TCGA patient cohorts, RNA activity of the Lactate transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STK10, SERPINB9, and FES, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lactate transmembrane transport activity versus STK10 in HNSC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	STK10 →	+0.450	+0.109	<.001	<.001	3	7
UCEC	SERPINB9 →	+0.462	+0.079	.001	.001	3	6
GBM	FES →	+0.565	+0.116	<.001	<.001	3	6
GBM	CAPZB →	+0.206	+0.114	<.001	<.001	3	6
GBM	AIF1_S39 →	+1.020	+0.128	<.001	<.001	3	6
GBM	GRAP2 →	+0.822	+0.129	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035873 vs STK10 — HNSC

Explore this scatter interactively →