Lactate transmembrane transport

Across TCGA patient cohorts, RNA activity of the Lactate transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERVFRD-1, WFS1, and ZNF668, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lactate transmembrane transport activity versus ERVFRD-1 in BRCA (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ERVFRD-1 →	-0.178	-0.624	.002	.007	3	4
CCRCC	WFS1 →	-0.441	-0.286	<.001	.001	3	3
CCRCC	ZNF668 →	-0.245	-0.282	.001	<.001	3	3
CCRCC	DUS1L →	-0.195	-0.253	.004	<.001	3	3
CCRCC	ZACN →	-0.241	-0.291	<.001	<.001	3	3
CCRCC	ERO1A →	+0.624	+0.295	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035873 vs ERVFRD-1 — BRCA

Explore this scatter interactively →