Lactate transmembrane transport

Across TCGA patient cohorts, RNA activity of the Lactate transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC16A1_S498, TMEM30A, and SEC61B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lactate transmembrane transport activity versus SLC16A1_S498 in CCRCC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SLC16A1_S498 →	+1.705	+0.328	<.001	<.001	3	6
BRCA	TMEM30A →	+0.409	+0.756	<.001	<.001	3	4
BRCA	SEC61B →	+0.500	+0.905	<.001	<.001	3	3
BRCA	EMP3 →	+1.230	+1.626	<.001	<.001	3	3
HNSC	RILPL2 →	+0.473	+0.203	<.001	<.001	3	3
BRCA	SLC2A3_S485 →	+0.889	+1.414	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035873 vs SLC16A1_S498 — CCRCC

Explore this scatter interactively →