Lactate transmembrane transport

Across TCGA cell cohorts, RNA activity of the Lactate transmembrane transport pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GALK1, STX3, and MGP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GALK1 grouped by Lactate transmembrane transport-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GALK1 →	-0.203	-0.269	.003	.002	2	6
LUNG_SCLC	STX3 →	+0.209	+0.263	.001	<.001	3	5
BREAST	MGP →	+0.114	+0.685	<.001	<.001	3	5
LUNG_NSCLC_LUSC	DLX2 →	-0.283	-0.367	.001	<.001	3	5
LARGE_INTESTINE	FOXP2 →	-0.209	-0.353	<.001	<.001	3	4
BLOOD_Leukemia	PKN3 →	-0.187	-0.177	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GALK1 by Lactate transmembrane transport activity — LUNG_SCLC

Explore this box plot interactively →