Lactate transmembrane transport

Across TCGA cell cohorts, RNA activity of the Lactate transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLG4, SETSIP, and HOMER2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lactate transmembrane transport activity versus DLG4 in PANCREAS (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DLG4 →	+1.720	+0.534	<.001	<.001	3	2
PANCREAS	SETSIP →	-0.594	-0.534	.005	<.001	3	2
PANCREAS	HOMER2 →	+1.784	+0.534	.008	<.001	3	1
PANCREAS	PPP1R37 →	-0.969	-0.534	.001	<.001	3	1
PANCREAS	FANCE →	-0.794	-0.534	<.001	<.001	3	1
PANCREAS	ZNF451 →	-0.699	-0.534	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035873 vs DLG4 — PANCREAS

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