"Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway"

Across TCGA patient cohorts, RNA activity of the "Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway" pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RENBP, and SASH3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway" activity versus RCSD1 in BRCA (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RCSD1 →	+0.602	+0.066	<.001	<.001	3	10
HNSC	RENBP →	+0.576	+0.097	<.001	<.001	3	10
OV	SASH3 →	+0.549	+0.064	<.001	<.001	3	10
OV	SKAP2 →	+0.831	+0.054	<.001	<.001	3	10
HNSC	STK10 →	+0.553	+0.090	<.001	<.001	3	10
GBM	TNFAIP8L2 →	+0.632	+0.085	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035872 vs RCSD1 — BRCA

Explore this scatter interactively →