"Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway"

Across TCGA patient cohorts, RNA activity of the "Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway" pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LHFPL2, TRAJ11, and CSF2RA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway" activity versus LHFPL2 in LUAD (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LHFPL2 →	+0.349	+0.624	.003	.006	3	4
LUAD	TRAJ11 →	+0.711	+0.651	.002	.004	3	4
LSCC	CSF2RA →	+0.427	+0.600	.004	.003	3	4
BRCA	ALDH3A2 →	-0.566	-0.475	.006	.009	3	3
GBM	C1orf115 →	-0.676	-0.348	.006	.009	3	3
HNSC	NSMF →	-0.438	-0.360	.005	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035872 vs LHFPL2 — LUAD

Explore this scatter interactively →