"Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway"

Across TCGA cell cohorts, RNA activity of the "Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway" pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADCY6, ARRDC1, and FBXO11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADCY6 grouped by "Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway"-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ADCY6 →	-2.224	-0.302	.009	.007	2	5
BREAST	ARRDC1 →	-1.124	-0.634	.001	<.001	3	4
KIDNEY	FBXO11 →	+0.661	+1.021	<.001	.002	3	3
KIDNEY	AASDH →	+0.720	+1.133	<.001	.001	3	3
STOMACH	EPHX2 →	-2.683	-0.934	.001	.008	3	3
STOMACH	IDNK →	-1.374	-0.682	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADCY6 by "Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway" activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →