"Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway"

Across TCGA cell cohorts, RNA activity of the "Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HYLS1, CTNNAL1, and SLC16A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway" activity versus HYLS1 in LUNG_NSCLC_LUAD (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	HYLS1 →	+0.715	+0.438	<.001	.009	3	4
URINARY_TRACT	CTNNAL1 →	+2.096	+0.868	.007	.008	3	4
URINARY_TRACT	SLC16A2 →	+2.478	+0.650	.003	.001	3	4
BREAST	ACOT9 →	+1.013	+0.382	.002	.004	3	4
LUNG_SCLC	FAM111B →	+1.341	+0.346	.004	.009	3	4
CNS	CDK5RAP1 →	+0.414	+0.646	.003	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035872 vs HYLS1 — LUNG_NSCLC_LUAD

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