Cellular response to potassium ion

Across TCGA patient cohorts, RNA activity of the Cellular response to potassium ion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GIMAP8, SASH3, and LCP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to potassium ion activity versus GIMAP8 in LSCC (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GIMAP8 →	-0.592	-0.066	<.001	.001	3	8
LSCC	SASH3 →	-0.491	-0.066	<.001	<.001	3	7
GBM	LCP2 →	-0.421	-0.066	<.001	<.001	3	7
OV	ADA →	-0.510	-0.071	<.001	<.001	3	7
GBM	PLEKHO2 →	-0.417	-0.094	<.001	<.001	3	7
LSCC	WDFY4 →	-0.640	-0.080	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035865 vs GIMAP8 — LSCC

Explore this scatter interactively →