Cellular response to potassium ion

Across TCGA patient cohorts, RNA activity of the Cellular response to potassium ion pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC12A2, CES3, and FAM160A1-DT, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to potassium ion activity versus SLC12A2 in BRCA (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC12A2 →	+1.254	+0.951	<.001	<.001	3	7
PDAC	CES3 →	+1.009	+0.820	<.001	<.001	3	4
BRCA	FAM160A1-DT →	+0.522	+0.670	<.001	<.001	3	4
LSCC	MSANTD3 →	-0.522	-1.051	.001	<.001	3	4
LSCC	RAD51AP1 →	-0.600	-0.814	.002	.001	2	5
LSCC	ANLN →	-0.723	-1.126	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035865 vs SLC12A2 — BRCA

Explore this scatter interactively →