Cellular response to potassium ion

Across TCGA patient cohorts, RNA activity of the Cellular response to potassium ion pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STK39_T354, REPS2_T479, and SLC12A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to potassium ion activity versus STK39_T354 in HNSC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	STK39_T354 →	+0.765	+0.417	<.001	<.001	3	5
BRCA	REPS2_T479 →	+0.825	+1.034	<.001	<.001	3	5
PDAC	SLC12A2 →	+0.699	+0.820	<.001	<.001	2	5
GBM	ATP1B1 →	+0.550	+0.329	<.001	<.001	3	4
BRCA	STK39_S371 →	+0.624	+0.646	<.001	<.001	3	4
HNSC	SLC12A2_S77 →	+0.691	+0.575	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035865 vs STK39_T354 — HNSC

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