Cellular response to potassium ion

Across TCGA cell cohorts, RNA activity of the Cellular response to potassium ion pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARP11, FAM160B1, and NKX2-5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PARP11 grouped by Cellular response to potassium ion-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PARP11 →	-1.910	-1.124	.001	.009	3	3
LUNG_NSCLC_LUSC	FAM160B1 →	-1.091	-1.201	<.001	.007	3	3
URINARY_TRACT	NKX2-5 →	-2.495	-0.383	.009	.002	3	3
OESOPHAGUS	MVB12B →	-0.975	-0.701	.001	.004	3	3
UPPER_AERODIGESTIVE_TRACT	TRIM14 →	+1.172	+0.722	.002	.009	2	4
SOFT_TISSUE	DCLK2 →	-1.839	-0.270	.008	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PARP11 by Cellular response to potassium ion activity — OESOPHAGUS

Explore this box plot interactively →