Cellular response to potassium ion

Across TCGA cell cohorts, RNA activity of the Cellular response to potassium ion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MGAT2, AP5S1, and TVP23C, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to potassium ion activity versus MGAT2 in BLOOD_Leukemia (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MGAT2 →	-0.597	-0.922	<.001	<.001	3	7
BLOOD_Myeloma	AP5S1 →	-0.731	-1.483	.009	<.001	3	6
BLOOD_Myeloma	TVP23C →	-2.302	-1.612	.003	<.001	3	5
OESOPHAGUS	SSH1 →	-1.328	-1.415	.009	.001	2	6
OESOPHAGUS	SLC23A2 →	-1.055	-1.278	<.001	<.001	3	5
BLOOD_Lymphoma	FOSL2 →	-4.022	-1.298	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035865 vs MGAT2 — BLOOD_Leukemia

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