Glial cell-derived neurotrophic factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Glial cell-derived neurotrophic factor receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TESPA1_S311, FAP, and SULF2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glial cell-derived neurotrophic factor receptor signaling pathway activity versus TESPA1_S311 in LSCC (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TESPA1_S311 →	-0.894	-0.116	<.001	<.001	3	6
HNSC	FAP →	+0.547	+0.086	<.001	<.001	3	6
BRCA	SULF2 →	+0.548	+0.080	<.001	<.001	3	6
GBM	CAMK4 →	-0.610	-0.130	<.001	<.001	3	6
GBM	SULF1 →	+0.906	+0.130	<.001	<.001	3	6
HNSC	HDHD2 →	-0.250	-0.091	.008	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035860 vs TESPA1_S311 — LSCC

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