Glial cell-derived neurotrophic factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Glial cell-derived neurotrophic factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are F2RL3, CCN2, and ISLR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glial cell-derived neurotrophic factor receptor signaling pathway activity versus F2RL3 in HNSC (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	F2RL3 →	+0.595	+0.360	.005	.006	3	4
OV	CCN2 →	+1.543	+0.718	.001	<.001	3	4
GBM	ISLR →	+0.959	+0.542	.003	.003	3	4
GBM	RAB3IL1 →	+0.451	+0.642	.006	.005	3	4
GBM	PDLIM7 →	+0.617	+0.524	<.001	.007	3	4
BRCA	LOXL1 →	+0.812	+0.334	.002	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035860 vs F2RL3 — HNSC

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