Glial cell-derived neurotrophic factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Glial cell-derived neurotrophic factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBX1, DNAJB6, and NGF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBX1 grouped by Glial cell-derived neurotrophic factor receptor signaling pathway-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	RBX1 →	-0.556	-1.859	.003	<.001	3	4
LUNG_NSCLC_LUSC	DNAJB6 →	-0.943	-1.461	.001	<.001	3	4
LUNG_NSCLC_LUSC	NGF →	-3.716	-1.766	<.001	<.001	3	4
LUNG_NSCLC_LUSC	ZNF665 →	-1.964	-1.594	.002	.002	3	4
KIDNEY	KCTD14 →	-1.547	-1.271	.002	.003	3	4
UPPER_AERODIGESTIVE_TRACT	IER5 →	-1.474	-1.522	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBX1 by Glial cell-derived neurotrophic factor receptor signaling pathway activity — BLOOD_Lymphoma

Explore this box plot interactively →