Glial cell-derived neurotrophic factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Glial cell-derived neurotrophic factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GDF15, SULF2, and SNRNP40, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glial cell-derived neurotrophic factor receptor signaling pathway activity versus GDF15 in STOMACH (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GDF15 →	+4.014	+0.797	<.001	.002	3	16
BLOOD_Myeloma	SULF2 →	+4.372	+1.266	<.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	SNRNP40 →	-0.752	-0.294	<.001	.001	3	11
KIDNEY	SGO1 →	-1.105	-0.361	.002	.005	3	11
LUNG_NSCLC_LUSC	SUV39H2 →	-0.654	-1.189	<.001	<.001	3	11
KIDNEY	TAF5 →	-0.713	-0.348	.002	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035860 vs GDF15 — STOMACH

Explore this scatter interactively →