Glial cell-derived neurotrophic factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Glial cell-derived neurotrophic factor receptor signaling pathway pathway is significantly associated with the drug response of multiple features, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are SB216763, GSK2606414, and PHA-793887, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SB216763 grouped by Glial cell-derived neurotrophic factor receptor signaling pathway-low versus -high activity in KIDNEY.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SB216763 →	+0.960	+0.313	.019	.014	3	1
KIDNEY	GSK2606414 →	+0.885	+0.313	.044	.014	3	1
KIDNEY	PHA-793887 →	-1.359	-0.330	.029	.012	3	1
KIDNEY	Mirin →	+0.464	+0.291	.016	.016	2	1
KIDNEY	Bleomycin (10 uM) →	-0.399	-0.291	.022	.016	2	1
KIDNEY	CHIR-99021 →	+0.770	+0.314	.036	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SB216763 by Glial cell-derived neurotrophic factor receptor signaling pathway activity — KIDNEY

Explore this box plot interactively →